Program
Tuesday, December 6th
12h00-14h00 Registration
12h45 Welcome
12h50-14h30 Symposium 1: “Tumor initiation”
Chaired by Natalia PREVARSKAYA and Florian LESAGE
Nobuaki Takahashi (University of Kyoto, Japan) - Oxidative Stress Defense in Cancer
Rainer Schindl (University of Graz, Austria) - Disease related STIM1 mutations that disturb store-operated channel activation
Ivan Bogeski (University of Gottingen, Germany) - Metabolic regulation of melanoma pathobiology: The role of calcium and redox signaling
Selected speaker
David Crottès (University of Tours, France) - Profiling of ion channels expression to investigate cancer heterogeneity
Coffee break
15h-18h00 “Calcium signaling in carcinogenesis, ECS session"
Chaired by Jan PARYS and Jim PUTNEY
Keynote - Jim Putney (Scientist Emeritus, NIEHS, USA) - Historical Perspective on Store-operated Calcium Channels
Juan Rosado (University of Extremadura, Spain) - Functional differences between Orai1α and Orai1β
Mohamed Trebak (University of Pittsburg, USA) - STIM proteins in colorectal cancer
Jonathan Soboloff (Temple University, Phyladelphia, USA) - Suppression of Ca2+ signaling enhances melanoma progression
Selected speaker
Flore Sneyers (KU Leuven, Belgium) - BAPTA directly inhibits PFKFB3, thereby impeding mTORC1-driven Mcl-1 translation and killing Mcl-1-addicted cancer cells
20h00 Social event « Dinner »
WEDNESDAY, December 7th
9h-10h30 Symposium 2: “Tumor growth”
Chaired by Loïc LEMONNIER and Bruno CONSTANTIN
Luis Pardo (Max-Planck-Institute, Germany) - Cell biological roles of Kv10.1 in physiology and pathophysiology
Olivier Soriani (University of Nice, France) - SK2 channels set a signaling hub bolstering CAF-triggered Tumorigenic processes in pancreatic cancer
Selected speakers
Isaac Jardin (University of Extremadura, Spain) - Differential translocation ability of Orai1α and Orai1β to the plasma membrane
Dimitra Gkika (University of Lille, France) - Non genomic regulation of TRPM8: from thermosensation to cancer
Coffee break
11h-12h30 Symposium 3: “Tumor cell migration and invasion”
Chaired by Dimitra GKIKA and Mustafa DJAMGOZ
Albrecht Schwab (University of Muenster, Germany) - Ionic signaling in pancreatic stellate cell migration
Konstantinos Konstantopoulos (Johns Hopkins, USA) - Counterintuitive effect of extracellular fluid viscosity on enhancing motility and metastasis
Selected speakers
Aubin Penna (University of Rennes, France) - The mechanosensitive TRPV2 calcium channel controls human melanoma invasiveness and metastatic potential
Rodrigo Cruz (New York University, USA) - SOCE modulates dysplasia to cancer in human oral squamous cell carcinoma
Lunch
13h40-14h Commercial presentation
14h-15h30 Symposium 4: “Therapy resistance”
Chaired by Charlotte DUBOIS and Olivier SORIANI
Barbara Ehrlich (Yale University, USA) - Neuronal calcium sensor 1 (NCS1) and cancer progression and treatment
Geert Bultynck (University of Leuven, Belgium) - Bcl-2 family and IP3 receptor inhibition underlying cancer cell death resistance
Selected speakers
Luca Matteo Todesca (University of Münster, Germany) - KCa3.1 inhibition decrease non-small cell lung cancer (NSCLC) migration via increased β1-integrin expression
Carlos Villalobos (University of Valladolid, Spain) - Polyamine depletion reverses transcriptomic remodeling and changes in intracellular calcium homeostasis in colon cancer cells
Coffee break
16h30-17h30 Plenary Lecture
Annarosa Arcangeli (University of Florence, Italy) - The channel complexes landscape in tumours: a novel perspective in oncological studies
17h30-19h30 Poster session
20h00 Dinner « Couvent des minimes »
THURSDAY, December 8th
8h30-10h30 Symposium 5: “Tumor microenvironment”
Chaired by Morad ROUDBARAKI and Halima AHIDOUCH
Xi Huang (University of Toronto, Canada) - Targeting ion channels in brain cancer
Germain Gillet (University of Lyon, France) - Role of Bcl-2 family proteins in development and tumor progression
Stine Pedersen (University of Copenhagen, Denmark) - Chronic acidosis rewires cancer cell metabolism through PPARalpha signaling
Selected speakers
Tatiana Varanita (University of Padova, Italy) - Myeloid cell-specific deletion of kv1.3 potassium channel determines tumor growth in vivo
Silviya Radoslavova (University of Lille) - Role of the extracellular matrix stiffness in pancreatic cancer cells and pancreatic stellate cells behavior
Coffee break
11h-12h30 Symposium 6: “Metabolism”
Chaired by Valerio FARFARIELLO and Carlos VILLALOBOS
Kevin Foskett (University of Pennsylvania, USA) - Pancreatic Ductal Cell Adenocarcinoma Growth, Proliferation, and Metastasis are Modulated by the Mitochondrial Ca++ Uniporter
Mustafa Naziroglu (Suleyman Demirel University, Turkey) - TRPM2 stimulation increases the antitumor action of cisplatin via the increase of mitochondrial oxidative stress and apoptosis in brain tumor cells
Selected speakers
Jan Parys (KU Leuven, Belgium) - Regulation of mitochondrial Ca2+ uptake and function by pyruvate kinase M2 (PKM2)
Hilda C. Delgado De la Herrán (Helmholtz Zentrum München, Germany) - Unbiased mapping of the MCU interactome reveals MCNR1 as a potential molecular target in cancer
Lunch
13h45-14h00
Artem Kondratsky (University of Lille) - Ion channels and cancer: global research trends, statistics, collaborations
14h-16h00 Symposium 7: “Therapeutic Targeting”
Chaired by V'yacheslav LEHEN'KYI and Yaroslav SHUBA
Ildiko Szabo (University of Padua, Italie) - Targeting the Achilles' heel of cancer cells: modulation of cell survival and migration by inhibition of mitochondrial ion channels
Saverio Gentile (University of South Carolina, USA) - Calcium signaling unveils cancer vulnerability: From bench science to clinical trial
Mustafa Djamgoz (Imperial College London, UK) - Ranolazine: A voltage-gated sodium channel blocker with clinical potential
Selected speaker
Nadine Déliot (CNRS, France) - Role of calcium entries in the physiopathology of glioblastoma stem cells
William J. Brackenbury (York Biomedical Research Institute, University of York UK) - Targeting the Nav1.5 channel with antiarrhythmic drugs to reduce metastatic recurrence: evidence from retrospective patient cohort studies
16h-16h15 Prizes ceremony and closure